Tools that allow physicians to provide the full value of CRT to patients by enabling patient specific optimization using MulitPoint™ Pacing and SyncAV™.

MultiPoint™ Pacing is safe: 93.6% freedom from system-related complications1 demonstrated by a prospective, multi-center, randomized, double-blinded clinical trial (IDE study: 506 patients in 49 centers)
MultiPoint™ Pacing is feasible: The IRON-MPP registry of 507 patients in 76 centers throughout Italy demonstrated that pacing the ability to provide MPP from 2 electrode locations with a good threshold and no PNS is feasible in the majority of patients2
MultiPoint™ Pacing increases response rates: a single center randomized study of 44 patients demonstrated a 44% relative reduction in non-responders and a 19% higher absolute response as measured by reduction in ESV at 12 months3

MultiPoint™ Pacing increases the magnitude of response: The same study demonstrated an improvement of the response with 34% «super-responders» (>30% ESV reduction)

MultiPoint™ Pacing is easy to program using VectSelect: wide spacing (> 30 mm) and nearly simultaneous activation (LV1-LV2: 5 ms) provide the best result as demonstrated by a subgroup analysis of the IDE study1

For patients with intrinsic atrio-ventricular (AV) conduction, dynamic CRT offered by SyncAV™ enhances the CRT effect by maintaining BiV pacing through automated adjustment of AV intervals during normal sinus rhythm to account for the individual patient’s AV conduction patterns 4. As a combination, MPP and SyncAV offer the unique opportunity for individualized CRT with reduction in the QRS duration and improved response to CRT.

References
1. Tomassoni, G., Baker II, J., Corbisiero, R., Love, C., Martin, D., Sheppard, R., Worley, S., Varma, N., Niazi, I. (2016). Safety and efficacy of multipoint pacing in cardiac resynchronization therapy: The MultiPoint Pacing (MPP) IDE Study. 2016 Heart Rhythm Society, LBCT 01-03

2. Forleo, G. B., Santini, L., Giammaria, M., Potenza, D., Curnis, A., Calabrese, V., . . . Zanon, F. (2016). Multipoint pacing via a quadripolar left-ventricular lead: Preliminary results from the Italian registry on multipoint left-ventricular pacing in cardiac resynchronization therapy (IRON-MPP). Europace, 1-8.

3. Pappone, C., Calovic, Z., Vicedomini, G., Cuko, A., McSpadden, L. C., Ryu, K., . . . Santinelli, V. (2015). Improving cardiac resynchronization therapy response with multipoint left ventricular pacing: twelve-month follow-up study. Heart Rhythm, 12, 1250-1258.

4. Wisnoskey, B. J., Cranke, G., Cantiion, D. J., & Varma, N. (2016). Feasibility of device-based electrical optimization via application of the negative AV hysteresis algorithm during cardiac resynchronization therapy (CRT). Heart Rhythm Society